Preparation of Pharmaceutical Powders

Details of preparation of Pharmaceutical Powders:

  1. Trituration:
    • Using a mortar and pestle or a mill, this procedure reduces the particle size of lumps or coarse granular materials. This approach is sometimes used to combine dry powder components as well.
Preparation of Pharmaceutical Powders-Trituration
  1. Pulverization:
    • In a mortar and pestle, it is challenging to powder sticky or soft materials. Such compounds are made powdered by adding an inert powdering aid and then removing it.
    • A common example is camphor, which is powdered by moistening in the presence of alcohol and allowing the alcohol to evaporate after processing.
  2. Levigation:
    • In this procedure, a solvent is used to turn the dry powder into a paste. This solvent is called as “Levigating Agent”.
    • Using a mortar and pestle, the powder-solvent paste is then triturated. This technique is used to make semi-solid dermatological preparations, ophthalmic ointments, and suspensions, which stops these formulations from feeling gritty.
    • Liquid Paraffin is an example of a common levigating agent.
  3. Spatulation:
    • This technique involves blending a little amount of powders by scrubbing a spatula over a small piece of paper or an ointment tile.
    • Small amounts of powder should only be processed using this method. This approach does not provide an uniform blending, hence powders with strong ingredients or in big quantities should not be blended.
    • Because eutectic mixes condense the particles, solid materials that create them are excellent for blending with spatulation.
    • By using this technique, chemicals including aspirin, camphor, menthol, phenol, and thymol can be mixed.
  4. Tumbling:
    • In this procedure, the powder is blended by tumbling in a revolving chamber using specialised motorised powder blenders. The procedure takes a long time.
  5. Sifter mixing:
    • Sifters are used to combine powders, creating goods that are light and fluffy. Potent medications cannot be added to a powder mixture using this procedure.

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