Difference Between Thin Layer and Paper Chromatography

TLC vs Paper Chromatography

Sr. No.	Point	Thin-layer chromatography (TLC)	Paper Chromatography
1	Principle	Thin-layer chromatography (TLC) is based on the adsorption principle.	This chromatography is based on the partition principle.
2	Mobile Phase	Mobile Phase can be liquid of gas.	The liquid will be the Mobile phase.
3	Stationary Phase	Glass plates or plastic sheets coated with a thin layer of a finely ground adsorbent, such as silica gel or alumina	Paper sheets or strips as the adsorbent material
4	In Organic Ion Analysis	Not properly suitable	Inorganic ions can also gladly be separated on paper chromatography than compare to thin-layer chromatography (TLC).
5	For color-forming agents & strong solvents	Thin-layer chromatography has a diverse benefit over paper chromatography in that the TLC plate or sheet is able to withstand color-forming agents & strong solvents	Not properly suitable
6	Type	Thin Layer Chromatography	1. Descending paper chromatography. 2. Ascending paper chromatography. 3. Radial paper chromatography. 4. Descending-Ascending paper chromatography. 5. Two dimensional paper chromatography.
7	Advantages	Corrosive reagents can be detectable. Easy in use for UV detection. Choice of Spray Reagents Automation can be done in TLC over Paper Chromatography Development Chamber Design can be easy than paper chromatography. The separation method is sharper. The sensitivity and spot of sample diffusion is very low.	It is a simple, low cost and hassle-free operations technique. Less preparation time & analysis time required The separation method is less sharp. The sensitivity and spot of sample diffusion is high than TLC.

TLC vs Paper Chromatography

Difference Between TLC and Paper Chromatography — Difference between paper and thin layer chromatography

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