Methods to Compare Dissolution Profiles
Two general approaches to compare dissolution profiles were examined:
- Model-independent approaches
- Model-dependent approaches.
The model-independent methods included
- ANOVA-based procedures,
- Ratio test procedures, and
- Pair-wise procedures.
The model-dependent approaches included
- zero-order
- first-order
- Hixson-Crowell
- Higuchi
- quadratic
- Weibull
- Gompertz
- logistic models.