Methods to Compare Dissolution Profiles

Methods to Compare Dissolution Profiles

Two general approaches to compare dissolution profiles were examined:

  1. Model-independent approaches
  2. Model-dependent approaches.

The model-independent methods included

  1. ANOVA-based procedures,
  2. Ratio test procedures, and
  3. Pair-wise procedures.

The model-dependent approaches included

  1. zero-order
  2. first-order
  3. Hixson-Crowell
  4. Higuchi
  5. quadratic
  6. Weibull
  7. Gompertz
  8. logistic models.

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